Patients after organ transplantation are under constant monitoring to determine proper organ function and immune status relating to the transplant. Particularly, the determination of the proper concentration of immunosuppressive drugs is standard today and is carried out very regularly. The suppression of the body's defense, which would quickly destroy the foreign organ, is imperative in transplant patients.
Recognizing the body’s rejection of the organ so early that serious damage can be avoided is very difficult with the existing methods.
A functional limitation in kidney transplant aftercare is that 50% loss of function might have already occurred, before a rejection of the transplant is recognized using the conventional serum creatinine measurement, with the risk of serious damage to the kidney.
The determination of the immunosuppressive drug concentration is very well suited to avoid side effects and overdoses, but has only limited significance for measuring the effectiveness of the immunosuppressive effect. Also, a constant high dosage of the immunosuppressive drug is not possible, since this leads to long-term damage to, for example, the kidney.
An immunosuppression drug treatment must always be as high as necessary to allow for organ acceptance by the patient’s body and as low as possible to minimize side effects - it is indeed a delicate balancing act.